Specialty Pharmacist Management and Monitoring of Prescription Cannabidiol (AEs, DDIs, and interventions)

This study evaluated how specialty pharmacists manage prescription cannabidiol. Pharmacists play an integral role in medication access, resulting in a high approval rate and all patients being able to access therapy. Due to multiple drug interactions with prescription cannabidiol, pharmacists commonly changed the dose of interacting medications. Patient counseling and support for AE management was also a pharmacists key role found in this study.
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Specialty pharmacy integration and the role of an advanced certified pharmacy technician in prescription cannabidiol access

The objective of this study was to measure time to medication access for prescription CBD from patient referral to first shipment when insurance approval process is managed by embedded specialty pharmacy team.Median time from initial assessment to first shipment was 7 days (IQR 4-13). Of patients for whom the CPhT helped obtain financial assistance (n = 14, 10%), all had $0 costs after assistance.
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Specialty pharmacist integration into an outpatient neurology clinic improves pimavanserin access

In this study, we found the time to access pimavanserin reduced by 21 days on average after pharmacist integration. Similarly, the rate of third party approval increased by 16% and treatment initiation increased by 18%.
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Persistence on Droxidopa for the Management of Orthostatic Hypotension at an Integrated Care Center

This was a single-center, retrospective analysis of persistence on droxidopa for the management of orthostatic hypotension in adults patients. This study also evaluated adherence, patient-reported adverse events and falls as well as healthcare resource utilization.
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DMT Persistence, Switches, and Discontinuation in Patients with Relapsing Multiple Sclerosis

This study of patients with RMS and ≥3 fills of DMT from a health-system specialty pharmacy evaluated DMT persistence. The probability of remaining persistent for 3 years was 0.51. Non-persistent patients mostly switched to a new DMT (39%), discontinued the DMT (26%) discontinued, or transferred care to a new specialty pharmacy or provider (27%). Specialty pharmacists played a key role in DMT transitions and initiated 7% of DMT discontinuations and 36% of DMT switches.
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Adherence to Disease Modifying Therapies at a Multiple Sclerosis Clinic: The Role of the Specialty Pharmacist

Vanderbilt Specialty Pharmacy (VSP) embeds pharmacists within an outpatient MS clinic to provide medication management and address barriers to adherence. We found an average adherence rate of 94% as measured by proportion of days covered (PDC), with 89% of all VSP patients achieving the industry standard of 80% PDC. Additionally, results indicate that ensuring financial assistance and low out-of-pocket costs are associated with high adherence to DMT within an integrated specialty clinic.
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Integrated Specialty Pharmacy Yields High PCSK9 Inhibitor Access and Initiation Rates

This study evaluated medication access rates in patients prescribed a PCSK9 inhibitor at a healthcare system with integrated specialty pharmacy services. Overall, 96% of prescriptions resulted in access to a PCSK9 inhibitor, with a median time to approval of 8 days. This high level of access supports this model as a best practice for prescribing PCSK9 inhibitor therapy.
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Exploring Rates of PCSK9 Inhibitor Persistence and Reasons for Treatment Non-Persistence in an Integrated Specialty Pharmacy Model

This study evaluates PCSK9i persistence at 2, 12 and 24 months after initiation of therapy, reasons for non-persistence and percent change in LDL.
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Assessing Patient-Reported Outcomes within an Inflammatory Bowel Disease Clinic at an Integrated Care Center

This study assessed patient-reported outcomes in patients prescribed specialty medications by an IBD clinic at a health system and dispensed by an integrated specialty pharmacy. A total of 515 MRQs were completed (median of 3 per patient; IQR 2, 3) during the study period. There were 2 reports of adverse effects and 11 reports of missing one or more medication doses. Medication effectiveness was rated as “excellent” in 13% (n=69) and “good” in 84% (n=433) of MRQ responses.

Multicenter Evaluation of Non-adherence to Self-injectable Biologic Therapy in Patients with IBD: Risk Factors and Health Outcomes

This study evaluated adherence rates and health outcomes across three academic centers with integrated specialty pharmacies. Centers with specialty pharmaies had high medicaiton possession ratio (MPR). Self-injectable biologic therapy non-adherence was associated with higher likelihood of emergency department visits and hospitalizations.