Austedo is a VMAT2i approved by the FDA for the treatment of HD chorea. We completed a retrospective chart review of 17 patients on doses higher than 48 mg/day that were followed for at least 6 months to describe safety outcomes. We also assess adherence, dose adjustments, and discontinuation rates of patients with HD receiving daily doses of DBZ at > 48 mg. A multi-site retrospective chart review was performed at two sites designated as HD Centers of Excellence.

Many barriers prevent individuals with substance use disorders from receiving hepatitis C virus (HCV) treatment. This study describes 96 patients with active HCV treated in an opioid use disorder bridge clinic model. Of 33 patients who initiated treatment, 25 patients completed treatment, and 13 patients achieved sustained virologic response.

This was a case series/descriptive report that aimed at describing patient characteristics, insurance access, and response to therapy in patients prescribed risankizuamab more frequently than the FDA-approved SQ maintenance dosing of 180mg or 360mg every 8 weeks. To date, no other data has been published to describe this topic.

This single-center, retrospective review evaluated medication outcomes and time to access therapy in patients using step therapy or formulary alternatives after being prescribed specialty medications for psoriasis or atopic dermatitis. Most patients denied specialty medications due to insurance requirements eventually needed them or were lost to follow-up (n=37; 60%). Only 5 patients (8%) benefited from and remained on step therapy.

This study described the care coordination process and patient outcomes from decision to treat with ustekinumab through initiating subcutaneous (SQ) injection. Prescriptions filled with Vanderbilt Specialty Pharmacy (VSP) had 2.5 times higher odds of being shipped in the appropriate window compared to non-VSP with 56% dose-escalated during the first year. This study shows ustekinumab initiation and escalation in the first year can be a lengthy process requiring a high level of care coordination.

This study quantified VSP pharmacists’ work performed to facilitate specialty medication education, access, adherence, and persistence for patients who do not use VSP. Across 3 clinics over 5 months, pharmacists performed 1,645 actions for 714 non-VSP patients, equating to 375 hours and $30,429.48 in estimated pharmacist compensation. Lack of visibility in the patient journey and increased workload on providers and health systems is created when payers and manufacturers lockout IHSSPs.

This quality improvement project aims to evaluate implementation of a standardized process for specialty pharmacists to document and monitor patient disease severity and response to therapy using the Short Inflammatory Bowel Disease Questionnaire (SIBDQ), a patient reported outcome, administered via the electronic health record patient portal.

This study evaluated treatment outcomes (adherence, persistence, switching and discontinuation of therapy) and pharmacists' management of adverse events (AE's) in patients on an oral oncolytic for CLL/SLL. In a population of patients initiating oral CLL/SLL therapy through an integrated Health-System Pharmacy, adherence to therapy was high (mean PDC 92%). Adverse effects led to 36% of therapy discontinuations and 72% of therapy switches, indicating an opportunity for pharmacists to manage AE's.

This study evaluated how allergic comorbidities affect dupilumab persistence when prescribed for asthma and chronic rhinosinusitis with nasal polyposis (CRSwNP). Non-persistence was 19% and 22% at 3 and 6 months, respectively. The median time to non-persistence was 66 days (IQR 25-95). Patients with commercial insurance and those with AERD were more likely to persistent.