Management of Patients with Multiple Sclerosis within Health-System Specialty Pharmacies: A Multisite Analysis of Patient outcomes, Pharmacist Actions, Adherence, and Persistence

This multisite, prospective, cohort study of patients with MS evaluated patient-reported outcomes, pharmacists' actions, and DMT adherence/persistence. Patients reported low rates of impacted productivity, hospitalization, and relapse due to MS. Pharmacists commonly provided medication education and actions to ensure DMT safety and adherence. Patients had a high rate of adherence (median PDC 88%) and persistence (86% at 12 months). Findings support positive outcomes for HSSP patients.
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Patient-centered monitoring for encorafenib and binimetinib: Tailoring patient education, monitoring, and outreach to improve health outcomes

This study assess the impact of pharmacist-led tailored monitoring for patients initiating encorafenib and binimetinib combination therapy. A retrospective study showed that in the first 90 days of treatment 44% of patients required at least 1 treatment interruption, 39% required at least 1 dose reduction, 11% discontinued therapy. A prospective study reporting the impact of implementing a pharmacist-led targeted monitoring program is forthcoming.

Patient tailored monitoring for patients initiating PARP inhibitor therapy

This study assess the impact of pharmacist-led tailored monitoring for patients initiating PARP inhibitor therapy. A retrospective study showed that all patients were able to access medicaiton through the pharmacist-led insurance approval process and 64% of patients required a treatment modification in the first 90 days of therapy. A prospective study reporting the impact of implementing a pharmacist-led targeted monitoring program is forthcoming.

Persistence to HIV pre-exposure prophylaxis filled through an integrated health-system specialty pharmacy compared with external pharmacies

This study compares persistence to HIV PrEP in patients filling their medication through an integrated health-system specialty pharmacy (HSSP) compared to those filling at external pharmacies. These findings demonstrate that patients were better maintained on PrEP therapy when their prescriptions were filled with the HSSP compared to external pharmacies, thus highlighting the role HSSPs can have in ending the HIV epidemic.
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Patient-reported Outcomes and Pharmacist Interventions in Neurology Specialty Disease States within an Integrated Care Center

This study evaluated patient-reported outcomes in neurology specialty disease states gathered via a monthly refill questionnaire. and corresponding pharmacist interventions. There was a high patient-reported adherence rate at 91%. Most pharmacist interventions focused on ensuring safe and effective medication use. Addressing recent healthcare utilization was the most common intervention.

Identifying rates, reasons, and correlates for non-adherence

This study evaluated reasons for nonadherence in a random 10% sample of the patients identified as nonadherent (PDC less than 80%) from the study below. We found that 40% of patients classified as nonadherent were misclassified, with 31% of those due to external fills, and 60% due to provider-recommended gaps in therapy. Most cases of true nonadherence were due to an inability to reach the patient.
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