Research Projects Page

Since our inception as an outcome committee in 2015, we have consistently and considerably expanded our ability to produce rigorous outcomes research. In 2018, we established a more formal program and leadership, including full time outcomes research staff. The result of these allocated resources has been a productive output across multiple specialty disease states. Below are highlighted outcomes from studies completed in recent years. 

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Research Project List

Research categories (field_research_categories)
Research categories (field_research_categories)
102 Results

Persistence to HIV pre-exposure prophylaxis filled through an integrated health-system specialty pharmacy compared with external pharmacies

This study compares persistence to HIV PrEP in patients filling their medication through an integrated health-system specialty pharmacy (HSSP) compared to those filling at external pharmacies. These findings demonstrate that patients were better maintained on PrEP therapy when their prescriptions were filled with the HSSP compared to external pharmacies, thus highlighting the role HSSPs can have in ending the HIV epidemic.

Access to Direct Acting Antiviral Therapy for Recipients of Solid Organs from Hepatitis C Viremic Donors

This study's findings indicate that access to DAAs in donor-derived HCV post-transplant is achievable and affordable; however, significant added administrative efforts may be required for insurance approval as well as obtaining copay assistance, which is a limited resource.
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Development, Implementation and Evaluation of a Health Outcomes and Research Program at an Integrated Health-System Specialty Pharmacy

The purpose of this descriptive report is to describe the development and results of this program. The Health Outcomes and Research Program began as an initiative for pharmacists to evaluate and convey the benefits they provide to patients, providers, and the health system. The Health Outcomes and Research Program described has pioneered outcomes research among HSSPs nationwide and has proven valuable to specialty pharmacists, the health system, and key specialty pharmacy stakeholders.
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Development of a Collaborative Pharmacy Practice Agreement to Improve Efficiency and Management of Prescribing in a Renal Transplant Clinic

Post-transplant patients require complex medication regimens to ensure the survival of the transplanted organ and patient overall well-being. These regimens are frequently adjusted, initiated, or discontinued within soon after transplant. Pharmacist expertise can be utilized to optimize post-transplant medication use. This study describes the creation and corresponding outcomes of a CPPA between pharmacists and physicians within a renal transplant clinic.
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Transitions of Care: A Focus on Specialty Medication Challenges and Specialty Pharmacist Opportunities

Adherence and persistence to specialty medications can be challenging during transitions in sites of care, provider types, specialty medications, and financial coverage changes. In this report, we review obstacles encountered within these transitions and the role of the specialty pharmacist in overcoming obstacles. Case examples for each type of specialty transition provide insight into the unique complexities faced by patients and shed light on pharmacists’ vital role in patient care.
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Comparison of provider satisfaction with specialty pharmacy services in integrated health-system and external practice models: A multisite survey

This multi-site, cross-sectional, online survey study of specialty clinic healthcare providers at ten academic health-systems with integrated specialty pharmacies was performed with the Vizient Specialty Pharmacy Outcomes and Benchmarking Workgroup. hese study results confirm that the health-system integrated specialty pharmacy practice model, implemented at institutions across the US, demonstrates high rates of provider satisfaction with services and perceived benefits.
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Impact of an Integrated Specialty Pharmacy Model on Patient Access to Dalfampridine

This study compared patient access to dalfampridine before versus after Vanderbilt Specialty Pharmacy obtained access to dispense the drug. Findings highlight how integrated specialty pharmacists can provide effective medication monitoring, counseling, and access when limited distribution networks are removed.
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A targeted approach to reducing rates of discontinuation and dose reduction in patients receiving sorafenib or regoranfenib

Sorafenib and regorafenib are oral multikinase inhibitors used to treat some cancers, but adverse events for both drugs are common and often cause patients to discontinue therapy or reduce their dose within several months of initiating therapy. This study found that a pharmacist-initiated tailored intervention reduced sorafenib and regorafenib discontinuations (29% to 13%) and dose reductions due to adverse reactions (18% to 13%).