Research Projects Page

Since our inception as an outcome committee in 2015, we have consistently and considerably expanded our ability to produce rigorous outcomes research. In 2018, we established a more formal program and leadership, including full time outcomes research staff. The result of these allocated resources has been a productive output across multiple specialty disease states. Below are highlighted outcomes from studies completed in recent years.

Research Project List

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Getting To Specialty Treatment In Dermatologic Inflammatory Conditions: Treatment Requirements And Patient Journey

Frequently patients are referred to the specialty pharmacy that do not meet the insurance step therapy requirements. We looked at patients with either atopic dermatitis or psoriasis that did not meet insurance step therapy requirements and the outcome after trying the insurance required treatments.

Persistence to HIV pre-exposure prophylaxis filled through an integrated health-system specialty pharmacy compared with external pharmacies

This study compares persistence to HIV PrEP in patients filling their medication through an integrated health-system specialty pharmacy (HSSP) compared to those filling at external pharmacies. These findings demonstrate that patients were better maintained on PrEP therapy when their prescriptions were filled with the HSSP compared to external pharmacies, thus highlighting the role HSSPs can have in ending the HIV epidemic.

Pharmacist Interventions to Improve Specialty Medication Adherence

This randomized prospective study evaluated the effectiveness pharmacist interventions had on specialty medication adherence using proportion of days covered (PDC). After 8 months post-enrollment, median PDC in the intervention group was significantly higher than the control group. Currently, 3 products related to this research are below:

2022 ASHP Survey of Health-System Specialty Pharmacy Practice: Clinical Services

This multi-phased survey aggregated data to describe clinical services provided by health-system specialty pharmacies (HSSPs). Results demonstrate that HSSPs are a clinical and educational resource for specialty clinics and have developed robust patient care services that encompass the patient journey from before specialty medication selection through treatment monitoring and optimization.

Exploring healthcare providers' experiences with specialty medication and Limited Distribution Networks

The goal of this study was to explore healthcare providers’ experiences with specialty medications distributed via Limited Distribution Networks (LDN) that do not include IHSSPs. Participants reported barriers to navigating LDNs that can interfere with clinic workflow and patient care. IHSSPs may reduce clinic burden by helping patients access, afford, and remain on therapy.

Access to Direct Acting Antiviral Therapy for Recipients of Solid Organs from Hepatitis C Viremic Donors

This study's findings indicate that access to DAAs in donor-derived HCV post-transplant is achievable and affordable; however, 35% of patients required an insurance appeal requiring significant administrative efforts. Additionally, patients not able to use the on-site specialty pharmacy and those requiring an insurance appeal were 5.8 and 5 times more likely to experience a delay in treatment initiation.

Specialty Medication Adherence Rates in Patients with Rheumatoid Arthritis across Health-System Specialty Pharmacies

This study evaluated rates of adherence to biologic DMARDS, measured by proportion of days covered (PDC), across 20 health-system specialty pharmacies through the Health-System Specialty Pharmacy Outcomes Research Consortium. The final median PDC after accounting for appropriate gaps in therapy was high at 95% (IQR, 0.87-0.99), demonstrating the benefits of health-system specialty pharmacies in helping patients with RA remain on effective therapies.

Development of a Collaborative Pharmacy Practice Agreement to Improve Efficiency and Management of Prescribing in a Renal Transplant Clinic

Post-transplant patients require complex medication regimens to ensure the survival of the transplanted organ and patient overall well-being. These regimens are frequently adjusted, initiated, or discontinued within soon after transplant. Pharmacist expertise can be utilized to optimize post-transplant medication use. This study describes the creation and corresponding outcomes of a CPPA between pharmacists and physicians within a renal transplant clinic.

Comparison of provider satisfaction with specialty pharmacy services in integrated health-system and external practice models: A multisite survey

This online survey study of specialty clinic providers at 10 health-systems evaluated quality of services of integrated and external specialty pharmacies. The mean (SD) score for overall satisfaction with integrated specialty pharmacies was significantly higher than the score for satisfaction with external specialty pharmacies: 4.72 (0.58) vs 2.97 (1.20) out of 5; P

Development, Implementation and Evaluation of a Health Outcomes and Research Program at an Integrated Health-System Specialty Pharmacy

This descriptive report details the development and early results of the VSP Health Outcomes and Research Program. Started as an initiative for pharmacists to evaluate and convey the benefits they provide to patients, providers, and the health system, the Program has pioneered outcomes research among HSSPs nationwide and has proven valuable to specialty pharmacists, the health system, and key specialty pharmacy stakeholders.