Research Projects Page

Since our inception as an outcome committee in 2015, we have consistently and considerably expanded our ability to produce rigorous outcomes research. In 2018, we established a more formal program and leadership, including full time outcomes research staff. The result of these allocated resources has been a productive output across multiple specialty disease states. Below are highlighted outcomes from studies completed in recent years. 

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Research Project List

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112 Results

Impact of an Integrated Specialty Pharmacy Model on Patient Access to Dalfampridine

This study compared patient access to dalfampridine before versus after Vanderbilt Specialty Pharmacy obtained access to dispense the drug. Findings highlight how integrated specialty pharmacists can provide effective medication monitoring, counseling, and access when limited distribution networks are removed.
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A targeted approach to reducing rates of discontinuation and dose reduction in patients receiving sorafenib or regoranfenib

Sorafenib and regorafenib are oral multikinase inhibitors used to treat some cancers, but adverse events for both drugs are common and often cause patients to discontinue therapy or reduce their dose within several months of initiating therapy. This study found that a pharmacist-initiated tailored intervention reduced sorafenib and regorafenib discontinuations (29% to 13%) and dose reductions due to adverse reactions (18% to 13%).

Specialty Medication Adherence Rates in Patients with Rheumatoid Arthritis across Health-System Specialty Pharmacies

This study evaluated rates of adherence to biologic DMARDS, measured by PDC, across 20 health-system specialty pharmacies through the Health-System Specialty Pharmacy Outcomes Research Consortium. High rates of adherence to biologic DMARDs were seen across 20 health-systems specialty pharmacies, demonstrating the benefits of health-system specialty pharmacies in helping patients with RA remain on effective therapies.
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Implementation of a Standardized Specialty Pharmacist Documentation Tool Within the Electronic Health Record in an Integrated Outpatient Dermatology Clinic

We implemented a standardized documentation tool (SmartForms) that would collect discrete data fields during the specialty pharmacist's workflow in Dermatology clinic. This allowed us to collect data for reporting purposes on the front end, save time, document pharmacist interventions prior to treatment initiation, improve Epic documentation visibility and future usability.

Assessing Patient-Reported Outcomes within an Integrated Health System Specialty Pharmacy

This study collected patient-reported side effects, missed doses, and perceived medication effectiveness for 1,398 patients over 3 months. Patient-reported side effects impact adherence and perceived medication effectiveness. Patients filling specialty medications within an integrated health system specialty pharmacy reported low rates of missed doses and side effects.

Persistence of Vesicular Monoamine Transport 2 Inhibitor Therapy for Tourette Syndrome and Chronic Tic Disorders

Persistence of Vesicular Monoamine Transport 2 Inhibitor Therapy for Tourette Syndrome and Chronic Tic Disorders

Assessing Patient-reported Outcomes and Pharmacist Interventions in Patients Prescribed Specialty Medications for Dermatology and Asthma, Sinus, and Allergy

Patient reported outcomes can be used to measure therapeutic response, as well as overall health status, functioning, quality of life, and disease management. Patients with inflammatory conditions who fill medication within an integrated HSSP model reported low rates of missed doses and side effects, and most rated high perceived medication effectiveness.

Assessing Patient-Reported Outcomes and Pharmacist Interventions in Multiple Sclerosis within an Integrated Care Center

The objective of this study was to assess PROs and pharmacist interventions in patients prescribed specialty MS medications at a health system with an integrated specialty pharmacy. We concluded that patients filling medication from our integrated health system specialty pharmacy model reported low rates of missed doses and side effects, and most rated high perceived effective medication use.