Research Projects Page

Ivosidenib is the first approved oral, targeted, small molecule inhibitor of the isocitrate dehydrogenase 1 (IDH1) mutation seen in acute myeloid leukemia. This review article discusses the clinical trials and dose escalation studies conducted to secure the U.S. Food and Drug Administration approval.

In this study, we conducted a quality improvement initiative to increase the number of patients taking standard of care maintenance therapies, including cystic fibrosis transmembrane receptor (CFTR) modulators. With implementation of a specialty pharmacist directed protocol, rate of standard of care medication use increased for all therapies. The highest rate of increase was in CFTR modulator use.

This article discusses development of a quality measures tool to track outcomes for self-injectable biologic therapy used in the management of inflammatory bowel disease. Through a collaborative initiative, a set of clinical and specialty pharmacy quality measures was developed to assess outcomes such as patient safety, disease status, treatment efficacy, and healthcare resource utilization.

This multi-site study evaluated the effectiveness of a clinical pharmacist-driven HCV delivery model in an open system. With an overall sustained virologic response (SVR) rate of 95% (per protocol), the clinical pharmacist-driven HCV treatment model was found to be effective and comparable to other real-world studies with specialist, non-specialist, and non-hepatology providers.

We performed a retrospective cohort analysis of adult patients with PAH who were prescribed PDE-5I therapy by the center’s outpatient pulmonary clinic and who received medication management through the center’s specialty pharmacy. Patients receiving PDE-5I therapy through an integrated model achieved high adherence rates and low OOP costs.

Our goal was to develop and evaluate a prediction model of HCV treatment failure. Most likely predictors of treatment failure in our dataset were older age, presence of hepatocellular carcinoma, and private versus public insurance, which appeared in 89%, 84%, and 80% of bootstrap models, respectively.

Pharmacy technicians facilitate medication refills for patients following transplant by conducting phone calls and scheduling medication shipments. Standard prescribing of these medications required calls to be made every 30 days. However technician’s ability to service an increasing number of patients was limited by high call volume workload. In this study, we found that converting medication supply from 30 to 90-days reduced daily call volume and allowed the technician to service more patients

This study evaluated the impact of non-adherence on healthcare utilization (hospitalizations, emergency department visits and prednisone use).

This study evaluated the response to adalimumab dose intensification (defined as a change in adalimumab therapy with reinduction or an increase in dosing frequency) in pediatric patients with inflammatory bowel disease.

This evaluation assessed the impact of a pharmacist-managed lithium consult service. Implementation of this service resulted in an increase in obtaining a serum lithium level within 24 hours of hospitalization as well as time savings to providers.