Research Projects Page

Since our inception as an outcome committee in 2015, we have consistently and considerably expanded our ability to produce rigorous outcomes research. In 2018, we established a more formal program and leadership, including full time outcomes research staff. The result of these allocated resources has been a productive output across multiple specialty disease states. Below are highlighted outcomes from studies completed in recent years.

Research Project List

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111-120 of 123 results

Adherence to Disease Modifying Therapies at a Multiple Sclerosis Clinic: The Role of the Specialty Pharmacist

Vanderbilt Specialty Pharmacy (VSP) embeds pharmacists within an outpatient MS clinic to provide medication management and address barriers to adherence. We found an average adherence rate of 94% as measured by proportion of days covered (PDC), with 89% of all VSP patients achieving the industry standard of 80% PDC. Additionally, results indicate that ensuring financial assistance and low out-of-pocket costs are associated with high adherence to DMT within an integrated specialty clinic.

The Hepatitis C Cascade of Care for Traditional versus Emergency Department Referrals

Universal HCV screening was recently suggested to have the biggest impact on cascade of care improvement. The objective of this study was to compare cascade of care completion rates among patients referred for HCV treatment from traditional referral sources to those referred from the emergency department. We found that patient demographics vary between the two referral sources and patients referred from the emergency department had significantly lower linkage and engagement in HCV care.

Building a Hepatitis C Clinical Program: Strategies to Optimize Outcomes

An increasing number of specialists and non-specialists are developing clinical programs to treat and cure hepatitis C virus (HCV). The goal of this paper is to evaluate and describe optimal strategies to improve outcomes related to HCV care delivery.

Advancing Patient Care through Specialty Pharmacy Services in an Academic Health System

Pharmacists at health system-based specialty pharmacies have the opportunity to improve patient care by providing comprehensive medication management for patients prescribed specialty medication. This manuscript describes how Vanderbilt Specialty Pharmacy integrated pharmacy services into existing outpatient specialty disease clinics at Vanderbilt University Medical Center, which improved patient access to therapy and continuity of care.

Optimizing the Hepatitis C Cascade of Care in the Direct-Acting Antiviral Era

The objective of this study was to identify factors associated with movement through the HCV CoC after referral to a multidisciplinary ID clinic to sustained virologic response (SVR), including both general and historically difficult to treat populations.

Early Outcomes Using Hepatitis C–Positive Donors for Cardiac Transplantation in the Era of Effective Direct-Acting Anti-Viral Therapies

Given the shortage of suitable donor hearts for cardiac transplantation, and the favorable safety and efficacy of current agents used to treat hepatitis C virus(HCV), our institution recently piloted transplantation of select patients using HCV-positive donors. In the era of highly effective DAAs, the use of HCV-positive donors represents a potential approach to safely expand the donor pool.

Retreatment Options Following HCV Direct Acting Antiviral Failure

Based on recent clinical trial data, most patients who fail HCV treatment with direct acting antiviral agents now have excellent retreatment options. In this article, we review the current state of the evidence for HCV retreatment after DAA failure.

Factors impacting teriparatide completion

In this study, we explored factors related to teriparatide completion. We found that patients utilizing VSP services were 62% more likely to complete teriparatide and 49% less likely to drop out of treatment after completing 12 months of teriparatide compared to non-VSP patients. Additionally, most patients (64%) required the use a financial assistance program only available to VSP patients. Smoking status also significantly impacted teriparatide completion.

Adjustments to Antiretroviral Therapy Regimens in Co-Infected Human Immunodeficiency Virus and Hepatitis C Virus Patients

This study describes a real world cohort of HIV/HCV co-infected patients in an outpatient infectious diseases clinic with a focus on the frequency and impact of HIV antiretroviral adjustments required prior to HCV direct acting antiviral initiation.

An Interdisciplinary Team Approach to Hepatitis C Evaluation and Treatment: Assessing the Impact of Clinical Pharmacist Involvement on HCV Clinical Practice and Treatment

This study demonstrated the benefits of pharmacist integration into an interdisciplinary to treatment patients with chronic HCV. Pharmacist integration resulted in improved patient engagement, reduced provider burden, and increased rate of HCV treatment.