Research Projects Page

Since our inception as an outcome committee in 2015, we have consistently and considerably expanded our ability to produce rigorous outcomes research. In 2018, we established a more formal program and leadership, including full time outcomes research staff. The result of these allocated resources has been a productive output across multiple specialty disease states. Below are highlighted outcomes from studies completed in recent years.

Research Project List

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111-120 of 140 results

Venetoclax-Based Salvage Therapy for Post-Hematopoietic Cell Transplantation Relapse in Acute Myeloid Leukemia

Published December 1, 2019
This study looked at 21 acute myeloid leukemia patients who had received a hematopoietic cell transplant and experienced relapsed disease. Each patient underwent salvage therapy with a venetoclax- based treatment regimen. Nineteen patients were assessed for treatment response and 12 of the 19 patients responded to venetoclax-based salvage therapy, leading to a 63.2% response rate.
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Evaluating Prescription Outcomes for Specialty Agents used to Treat Dermatologic Conditions: A Quality Improvement Initiative

Published December 1, 2019
In this initiative, we evaluated outcomes following prescription of specialty dermatology medications in biologic-naïve patients. Of the 28 prescriptions evaluated, median time to approval was 9 days, with delays resulting from the need for a pharmacist to ascertain clinical data such as disease severity and treatment history.
View Derm Rx Outcomes for Specialty Agents QJ Poster. September 2020

Identifying rates, reasons, and correlates for non-adherence

Published November 25, 2019
This study evaluated reasons for nonadherence in a random 10% sample of the patients identified as nonadherent (PDC less than 80%) from the study below. We found that 40% of patients classified as nonadherent were misclassified, with 31% of those due to external fills, and 60% due to provider-recommended gaps in therapy. Most cases of true nonadherence were due to an inability to reach the patient.
View Nonadherence to Identify Opportunities Poster. September 2018
View Identifying Nonadherence Rates and Reasons Poster. October 2018
View Rates and Correlates of Nonadherence Poster. March 2019
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Pharmacologic Management of HCV Treatment in Patients with HCV Monoinfection vs. HIV/HCV Coinfection: Does Coinfection Really Matter?

Published November 21, 2019
In this ambispective cohort study of patients referred to an outpatient Infectious Diseases Clinic for chronic HCV, we found significant differences in patient demographics, drug interactions, and time to treat between HCV monoinfected and HIV/HCV coinfected patients. This study provides a broad, yet concise overview of the differences in caring for patients with and without HIV/HCV coinfection.
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Ivosidenib: IDH1 Inhibitor for the Treatment of Acute Myeloid Leukemia

Published October 1, 2019
Ivosidenib is the first approved oral, targeted, small molecule inhibitor of the isocitrate dehydrogenase 1 (IDH1) mutation seen in acute myeloid leukemia. This review article discusses the clinical trials and dose escalation studies conducted to secure the U.S. Food and Drug Administration approval.
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Healthcare Provider Attitudes and Knowledge Around Pre-Exposure Prophylaxis (PrEP) for the Prevention of HIV-Infection in Tennessee

Published October 1, 2019
In the Southern US, HIV prevalence is disproportionately high and PrEP use is disproportionately low. This cross-sectional survey study assessed Tennessee primary care providers’ current PrEP knowledge, attitudes, and prescribing practices with the aim to determine barriers to PrEP provision specific to TN providers.
View Provider Attitudes and Knowledge Poster. October 2019

Implementing a Medication Reconciliation Protocol for Adult Cystic Fibrosis Patients in an Integrated Outpatient Clinic

Published October 1, 2019
In this study, we conducted a quality improvement initiative to increase the number of patients taking standard of care maintenance therapies, including cystic fibrosis transmembrane receptor (CFTR) modulators. With implementation of a specialty pharmacist directed protocol, rate of standard of care medication use increased for all therapies. The highest rate of increase was in CFTR modulator use.
View Poster. October 2019

Navigating the Wild West of Medication Adherence Reporting in Specialty Pharmacy

Published September 26, 2019
This article highlights the challenges in standardizing adherence methodologies as well as the key elements to consider when interpreting adherence results. Specialty pharmacies should consider using adherence measures to identify and intervene on patients with adherence challenges. In addition, integrated specialty pharmacies should work to link adherence to clinical outcomes and healthcare cost savings.
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Development of a Quality Measures Tool for the Use of Self-Injectable Biologic Therapy in Inflammatory Bowel Disease: An Integrated Specialty Pharmacy Initiative

Published August 16, 2019
This article discusses development of a quality measures tool to track outcomes for self-injectable biologic therapy used in the management of inflammatory bowel disease. Through a collaborative initiative, a set of clinical and specialty pharmacy quality measures was developed to assess outcomes such as patient safety, disease status, treatment efficacy, and healthcare resource utilization.
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Expanding Hepatitis C Virus Care and Cure: National Experience Using a Clinical Pharmacist-Driven Model

Published July 3, 2019
This multi-site study evaluated the effectiveness of a clinical pharmacist-driven HCV delivery model in an open system. With an overall sustained virologic response (SVR) rate of 95% (per protocol), the clinical pharmacist-driven HCV treatment model was found to be effective and comparable to other real-world studies with specialist, non-specialist, and non-hepatology providers.
View Poster. November 2018
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